1. 两者都可表示“在……期间”，但 during 是介词，而 while 是连词。如：

他在巴黎期间，与他的朋友住在一起。

误：During he was in Paris, he lived with his friends.

误：During in Paris, he lived with his friends.

正：While he was in Paris, he lived with his friends.

正：During his stay in Paris, he lived with his friends.

2. 两者都可表示在某一段时间内所发生的某一点动作，其区别仍然是：during 为介词，while 为连词。如：

He died during the night. 他死于夜间。

He fell asleep while he was reading. 他在读书时睡着了。